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As with any new location in Honkai Star Rail, there's a slew of chests to discover in tucked-away corners and unexpected spots. As we venture into the Alchemy Commission location, there is much to uncover.
In total, there are about 22 treasure chests in the area, filled with rewards such as Stellar Jade. This includes the chests you'll receive from completing the puzzles spread throughout the Alchemy Commission, involving battles with Formidable Foes and unlocking Navigation Compasses.
Alchemy Commission Chest Locations - Southern Region
In the above image, we have placed a red marker for each chest location in the southern region of the Alchemy Commission. We will go over each specific location, so you can more easily find the chests.
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Chest Number & Image |
Location |
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Chest 1 
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Found directly north of the Medicine Bureau Space Anchor. |
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Chest 2 
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Head north from the Medicine Bureau Space Anchor and up the stairs. The chest will be tucked in a corner past the Abomination enemies. |
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Chest 3 
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Head down the stairs from the Medicine Bureau Space Anchor. Past the cafe area, head down another flight of stairs where you'll spot the chest next to some benches. |
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Chest 4 
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Across from the last chest, sitting in front of a bench with a box on top. |
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Chest 5 
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You will need to complete a Courier Cycrane puzzle to get this chest. You'll find the Courier Cycrane directly south of the Healer's Market Space Anchor on the map. |
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Chest 6 
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Make your way up the flight of stairs south of the previous Courier Cycrane chest. You'll need to defeat the Formidable Foes up here to receive the chest. |
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Chest 7 
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Head northwest from the Courier Cycrane chest. The chest will be next to a flower pot. |
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Chest 8 
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Head southwest from the Courier Cycrane chest. Make your way down the flight of stairs, and then turn right and defeat the Formidable Foes here. |
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Chest 9 
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This one will require you to complete the Navigation Compass puzzle. It can be found at the bottom of the set of stairs, north of the previous chest. |
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Chest 10 
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Head just north of the Healer's Market Space Anchor. The chest will be hidden behind a few tables and pots. |
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Chest 11 
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Make your way southeast from the Healer's Market Space Anchor. This chest will be near the wall just before the bridge leading to Stagnant Shadow: Shape of Celestial, where you can find ascension materials for Blade. |
Alchemy Commission Chest Locations - Northern Region
For these chests, you'll find them in the northern region of the Alchemy Commission. There will also be one that will be located on the second level, which you can reach by using the Aureate Elixir Furnace Space Anchor.
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Chest Number & Image |
Location |
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Chest 12 
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Head northwest of the Healer's Market Space Anchor. Make your way up the staircase on the left, and head behind the building left of the bench to find the chest tucked in a corner. |
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Chest 13 
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Head north from the Healer's Market Space Anchor. This chest will be against another wall, close by to a bench. |
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Chest 14 
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This chest will be tucked in a corner past a couple Abomination enemies. It can be found southeast of the Aureate Elixir Furnace Space Anchor. |
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Chest 15 
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This chest will be on the second level of the Alchemy Commission. Start at the Aureate Elixir Furnace Space Anchor, and make your way around until you reach the center. It'll be on the right side. |
Alchemy Commission Chest Locations - Upper Level
These chests will be the remaining ones on the second level of the Alchemy Commission. There are seven total in this section, and they will start from the Elixir Research Terrace Space Anchor.
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Chest Number & Image |
Location |
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Chest 16 
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Head behind the small storefront next to the Elixir Research Terrace Space Anchor. The chest will be here. |
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Chest 17 
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Make your way south from the Elixir Research Terrace Space Anchor. Follow down the staircase on the west, and the chest will be to the right. |
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Chest 18 
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This chest can be found just north of the previous one, after you solve the Navigation Compass puzzle. |
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Chest 19 
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Go directly south from the Elixir Research Terrace Space Anchor. On the left underneath the bridge, you'll find the chest between two benches. |
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Chest 20 
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From the previous chest, make your way up the staircase to the north. Then, head south past a few Abomination enemies and through the entryway. There will be a Courier Cycrane waiting here, which you will need to lead to its correct location. |
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Chest 21 
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This one will be another Courier Cycrane puzzle. It can be found directly south of the 19th chest. |
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Chest 22 
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Make your way southeast of the previous chest. You'll need to defeat the Formidable Foe here to get the final chest. |