If you've been perusing Diablo 4's online communities as you play the game, you may have noticed that some players' HUDs are in a different spot on the screen than yours, and they have a different layout when it comes to their health, skills, and resources.
Though the official options for HUD variety aren't that plentiful, there are at least two layouts Blizzard lets you choose between. It's worth it to give each of them a try to see what works best for you, however, it can be difficult to find where the HUD can be changed, due to Diablo 4's various menu screens.
Updated by Jose Garcia on June 30, 2023: Added several new links throughout, as well as refreshed the images to be more relevant to the material covered.
How To Change Your HUD
First, you'll want to open up your map. From there, you'll scroll to the far right menu tab, which will be titled 'Game.' In 'Game,' press 'Options', then, in 'Options,' scroll right toward the tab labeled 'Gameplay.'
Down the list of Gameplay options, you should see that one of them is labeled 'HUD Configuration.' Your two choices here are 'Centered' and 'Left Corner.'
Your HUD Options
In the 'Left Corner' style, you have a clearer view of the center of the screen, which is valuable as the game camera always keeps the player at center focus, so you'll have a better view of the enemies and allies that are right below you.
Furthermore, this layout has a larger health orb, and it's also elevated in comparison to the rest of the HUD, making it easier to check mid-battle. This is obviously useful, as your health is the first thing you should keep track of in combat.
The secondary 'Centered' option has everything... centered. For some players, this may make everything easier to track as it's closer to the middle of the screen. It's particularly useful for glancing down at ability cooldowns, which could be harder to notice when they're tucked in the bottom left. Ultimately, it's a matter of preference. Now you know your two options, so choose the one that works best for you!